What is an example of alternative splicing?
Collectively such genes are considered to undergo complex alternative splicing. The best example is the Drosophila Down syndrome cell adhesion molecule (Dscam) gene, which can generate 38,016 isoforms by the alternative splicing of 95 variable exons.
What is the most common type of alternative splicing in animals?
There are numerous modes of alternative splicing observed, of which the most common is exon skipping. In this mode, a particular exon may be included in mRNAs under some conditions or in particular tissues, and omitted from the mRNA in others.
Can bacteria be substituted splice?
Alternative splicing during intracellular bacterial infections of macrophages is more pervasive than possibly ever imagined. Global changes in the alternative splicing during bacterial infection have been shown in the case of Salmonella and Listeria [29].
Do prokaryotes use alternative splicing?
Is there alternative splicing in prokaryotes? Alternative splicing if referred to that of non-coding mRNA does occur in prokaryotes. Prokaryotic mRNA does not require splicing to remove introns and join the exons, unlike that in eukaryotes.
Is there alternative splicing in prokaryotes?
What is the evolutionary landscape of alternative pre-mRNA splicing in Drosophila?
Alternative pre-mRNA splicing (“AS”) greatly expands proteome diversity, but little is known about the evolutionary landscape of AS in Drosophila and how it differs between embryonic and adult stages or males and females.
Are there species-specific splicing differences in Drosophila exons?
Species-specific splicing differences in Drosophila therefore may be based mostly on the binary category of whether an exon is alternatively spliced or constitutive rather than on differences in Ψ values of orthologous exons among species.
Do alternative splicing profiles cluster samples by species rather than tissue?
Alternative splicing profiles cluster samples by species rather than tissue (with the exception of head) into adulthood, suggesting that alternative splicing has diverged more than gene expression levels among Drosophila species.
What is alternative pre-mRNA splicing (as)?
Alternative pre-mRNA splicing (“AS”) greatly expands the proteome diversity within and between species by creating different combinations of exons from the same genomic loci.
