What is anti TGF-beta?
Anti-TGF-beta monoclonal antibody GC1008 may help keep cancer cells from growing and prevent the growth of new blood vessels that tumors need to grow. It is a type of monoclonal antibody and a type of antiangiogenesis agent. Also called fresolimumab and GC1008.
What is a TGF-beta test?
This is a quantitative EIA assay for the human cytokine Transforming Growth Factor beta 1 ( TGF ß-1). TGF β-1 plays a role in tissue regulation and is used as an aid to determine underlying causes of unusual or inflammatory disorders.
What is TGF-beta used for?
Transforming growth factor β (TGF-β) is a highly pleiotropic cytokine that plays an important role in wound healing, angiogenesis, immunoregulation and cancer. The cells of the immune system produce the TGF-β1 isoform, which exerts powerful anti-inflammatory functions, and is a master regulator of the immune response.
Is TGF-beta immunosuppression?
TGF-β is one of the main immunosuppressive cytokines produced by tumor-associated macrophages (TAMs), and as already mentioned, subsets of human macrophages can mobilize active TGF-β through the activity of integrin αvβ8 and MMP14 (Kelly et al., 2018).
What is the TGF-beta antibody?
* Avoid repeated exposure to skin. TGF-beta Antibody detects recombinant TGF-β1, TGF-β2, and TGF-β3. The antibody also detects endogenous levels of the TGF-β1 precursor proteins. Polyclonal antibodies are produced by immunizing animals with synthetic peptide corresponding to a region in the carboxy terminus of TGF-beta1.
What is anti-TGF beta 1 affinity purified antibody?
Rabbit Anti-TGF beta 1 affinity purified antibody is directed against human TGFb1 protein. A BLAST analysis was used to suggest reactivity with this protein from most mammalian sources based on 100% homology for the immunogen sequence.
What is TGF beta-1?
TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues.
Does TGF beta 1 inhibit IL-4?
TGF‑ beta 1 Inhibition of IL‑4-dependent Cell Proliferation and Neutralization by TGF‑ beta 1 Antibody. Recombinant Human TGF-beta 1 (Catalog # 240-B) inhibits Recombinant Mouse IL-4 (Catalog # 404-ML) induced proliferation in the HT-2 mouse T cell line in a dose-dependent manner (orange line).