What is brachyury expression?
Brachyury (T) is involved in mesoderm induction during early mouse development. T expression in embryonal carcinoma P19 cells, which differentiate into mesoderm derivatives in vitro, was studied. Endogenous T expression in P19 cells was transiently induced when the cells were allowed to form aggregates.
What is a chordoma tumor?
Chordoma is a slow growing cancer of tissue found inside the spine. Chordoma can happen anywhere along the spine. It is most often found near the tailbone (called a sacral tumor) or where the spine meets the skull (called a clival tumor). Chordoma is also called notochordal sarcoma.
What does the Brachyury gene do?
The BRACHYURY (T) gene is required for the formation of posterior mesoderm and axial development. In all vertebrates, the gene is initially expressed throughout the presumptive mesoderm, and during later stage, the expression is gradually restricted to the developing notochord and tail bud (3, 19, 20).
Why is Brachyury called?
The name brachyury comes from the Greek brakhus meaning short and oura meaning tail. In 2018 HGNC updated the human gene name from T to TBXT, presumably to overcome difficulties associated with searching for a single letter gene symbol. It is assumed that the mouse nomenclature will also be updated in due course.
What significant contribution does the gene Brachyury t make in animal development?
Role in development The gene brachyury appears to have a conserved role in defining the midline of a bilaterian organism, and thus the establishment of the anterior-posterior axis; this function is apparent in chordates and molluscs.
What is the cause of chordoma?
The underlying causes of chordoma are unknown. Most cases arise spontaneously and are not due to an inherited genetic change. A prevailing theory is that acquired genetic abnormalities or mutations result in cancerous growth of notochordal remnants.
What are Brachyury antibodies used for?
Antibodies that detect Brachyury can be used in several scientific applications, including Western Blot, Immunohistochemistry (Paraffin), Immunocytochemistry, Flow Cytometry and View more The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site.
What is the pathophysiology of parachordoma?
Parachordoma appears to be an entity with clinical and pathological differences from chordoma, which has a different cytokeratin profile, behaves in a more aggressive fashion, and can dedifferentiate. The differential diagnosis includes myxoid chondrosarcoma, myoepithelial cell tumor, ossifying fibromyxoid tumor, and chondroid lipoma.
Can Brachyury immunohistochemical staining be used for the differential diagnosis of chordoma?
Herein, the use of brachyury immunohistochemical staining for the differential diagnosis of chordoma and HBL towards neoplastic histological mimickers occurring in the same sites is discussed. 2. Brachyury for the Differential Diagnosis of Chordoma
Which immunohistochemical findings are characteristic of chordoma?
Again, the immunohistochemical detection of nuclear brachyury has been demonstrated to be a sensitive and specific marker for chordoma, in the differential diagnosis towards chordoid meningioma [7, 10].