What is CK19 positive?

CK19 positive tumors are associated with poor outcome irrespective of the established pathologic parameters such as size, mitoses, lymphovascular invasion, and necrosis. It is recommended that CK19 be part of the immunohistochemical panel in the work-up of pancreatic endocrine tumors.

What does PAX8 positive mean?

PAX8-positive, calretinin-negative staining appears to be highly specific and sensitive for detecting metastatic ovarian serous carcinoma in cytological preparations and may prove useful for distinguishing these cells from mesothelial cells in fluid cytology (32).

What kind of tumors grow on ovaries?

Most ovarian tumors are epithelial cell tumors. Germ cell tumors start from the cells that produce the eggs (ova). Stromal tumors start from structural tissue cells that hold the ovary together and produce the female hormones estrogen and progesterone.

What are the most common tumors metastatic to the ovary?

The two most common nongynecologic primary sites of ovarian metastasis were the colorectum (68 cases) and stomach (61 cases). In addition to the most common symptoms of abdominal distension (39.0%), abdominal pain (37.9%), and ascites (27.7%), 18.1% of patients presented with abnormal uterine bleeding.

What tumors are positive for PAX8?

These results show that PAX8 is a highly sensitive marker for thyroid, renal, Müllerian, and thymic tumors. Importantly, all lung adenocarcinomas, breast and adrenal neoplasms, and the majority of gastrointestinal tumors were negative for PAX8. Therefore, PAX8 is an excellent marker for confirming primary tumor site.

What does p16 positive mean?

Expression of p16INK4A (p16 positive) is highly correlated with human papilloma virus (HPV) infection in head and neck squamous cell carcinoma (HNSCC), however, p16-positivity is not limited to HPV positive tumors and therefore, not a perfect surrogate for HPV.

What is the most common malignant ovarian tumor?

Epithelial ovarian carcinomas: These are the most common type of ovarian cancer. About 85% to 90% of these cancers involve the cells that cover the outer surface of the ovary.

What is the most common benign ovarian tumor?

Benign epithelial tumours are the most common type of benign ovarian tumour. They start from the cells that cover the outer surface of the ovary. Their makeup can be mainly cystic (called cystadenoma), mainly solid (called adenofibroma) or mixed (called cystadenofibroma).

How fast do ovarian tumors grow?

Ovarian cancer grows quickly and can progress from early stages to advanced within a year. With the most common form, malignant epithelial carcinoma, the cancer cells can grow out of control quickly and spread in weeks or months.

What percent of ovarian tumors are cancerous?

Overall, they account for 20 to 25% of all tumors, benign as well as malignant, of the ovary. Approximately 3% are malignant.

What does CK19 positive endometrial carcinoma look like?

Endometrial carcinomas were also CK19 positive, but in most cases there was a distinct zonal pattern of expression with strong staining only in the central aspects of the larger tumor glands and weak-to-absent staining in peripheral glandular areas.

Is CK19 immunohistochemistry useful in pancreas and liver tumors?

CK19 immunohistochemistry has been used successfully in thyroid tumors to recognize papillary carcinomas for some time. However, its use in the pancreas, liver, and gastrointestinal tract (GIT) has only recently come to the fore. The purpose of this review is to look at the use of CK19 immunohistochemistry in tumors occurring at these sites.

Can ck17 and CK19 be used to predict the prognosis of cervical cancer?

Conclusion: Serum CK17 combined with serum CK19 is of great diagnostic and predictive significance for CC. Keywords: Cervical cancer, CK17, CK19, prognosis, serum Introduction Cervical cancer (CC), a significant cause of death among females, shows an increasing morbidity among developing countries [1,2].

What is the prognosis of CK19 positive pancreatic cancer?

CK19 positive tumors are associated with poor outcome irrespective of the established pathologic parameters such as size, mitoses, lymphovascular invasion, and necrosis. It is recommended that CK19 be part of the immunohistochemical panel in the work-up of pancreatic endocrine tumors.