Table of Contents
What is haloperidol made of?
A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety. This entity has been manually annotated by the ChEBI Team. Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication.
What is the prototype for haloperidol?
Haloperidol is a prototype of typical APDs, and the other three drugs are atypical APDs, which are effective in reducing negative symptoms and cognitive deficits of schizophrenia, cause less side effects, and are more tolerable compared to haloperidol.
What is haloperidol derived?
The discovery of haloperidol at the end of the 1950s constitutes one of the greatest advances of 20th century psychiatry. This antipsychotic drug has their origin in the research process of central analgesic molecules derived from pethidine and methadone, carried out by the Belgian company Janssen Phamaceutica.
How is haloperidol metabolized?
Haloperidol undergoes extensive metabolism in the liver, with only around 1% of the drug originally administered being excreted in the urine unchanged. The main mode of hepatic clearance is through glucuronidation, reduction and oxidation mediated by CYP3A4.
Is haloperidol a neuroleptic drug?
Neuroleptic malignant syndrome and QT interval prolongation may occur….Haloperidol.
| Clinical data | |
|---|---|
| Routes of administration | By mouth, intramuscular, intravenous, depot (as decanoate ester) |
| Drug class | Typical antipsychotic |
| ATC code | N05AD01 (WHO) |
| Legal status |
When was haloperidol invented?
1958
Paul A. J. Janssen at Janssen Pharmaceutica (Beerse, Belgium), discovered haloperidol in the mid-1950s. Clinical trials began in 1958, but the US Food and Drug Administration did not approve the medicine until 1967. It was first marketed by McNeil Laboratories (Fort Washington, PA) under the trade name Haldol.
What is the chemical name for haloperidol?
The IUPAC name of haloperidol decanoate is [4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl] decanoate.
What is the chemical name for clozapine?
Clozapine hydrochloride
| PubChem CID | 135524906 |
|---|---|
| Structure | Find Similar Structures |
| Molecular Formula | C18H20Cl2N4 |
| Synonyms | Clozapine hydrochloride 54241-01-9 UNII-80862U56A3 80862U56A3 3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine;hydrochloride More… |
| Molecular Weight | 363.3 |
Who invented haloperidol?
Paul A. J. Janssen
Paul A. J. Janssen at Janssen Pharmaceutica (Beerse, Belgium), discovered haloperidol in the mid-1950s.
What is the chemical name of haloperidol?
How does Haldol work in the brain?
Haldol works by inhibiting the effects of dopamine and increasing its turnover. Dopamine is a neurotransmitter, a signaling molecule in the brain, which is involved in motor control. The increased activity of dopamine is thought to cause chorea in Huntington’s disease.
Who invented Haldol?
Paul A. J. Janssen at Janssen Pharmaceutica (Beerse, Belgium), discovered haloperidol in the mid-1950s. Clinical trials began in 1958, but the US Food and Drug Administration did not approve the medicine until 1967. It was first marketed by McNeil Laboratories (Fort Washington, PA) under the trade name Haldol.
May be used in the treatment of schizophrenia.
Is Haldol a narcotic?
Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. Haloperidol is used in the treatment of schizophrenia, tics in Tourette syndrome, mania in bipolar disorder, delirium, agitation, acute psychosis, and hallucinations in alcohol withdrawal. It may be used by mouth or injection into a muscle or a vein.
What is antidote for haloperidol?
Orthostatic hypotension – (After IM injection of haloperidol),tachycardia,palpitation
How to give Haldol injection?
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