What is IL-2 Immunology?

Interleukin-2 (IL-2) is one of a family of polypeptides that mediate interactions between leukocytes. It was initially called T-cell growth factor. It stimulates proliferation and enhances function of other T-cells, natural killer (NK) cells and B-cells.

What is IL-2 a marker of?

Besides its potent T-cell growth factor activity, IL-2 induces proliferation of natural killer (NK) cells and augments their cytolytic activity as well as that of lymphokine-activated killer cells (Siegel et al., 1987), promotes antibody production and proliferation by B cells (Mingari et al., 1984), and is essential …

What is IL-2 chemo?

It is also known as interleukin 2 (IL-2) or by its brand name Proleukin. It is a treatment for kidney cancer that has spread to another part of the body (advanced kidney cancer). It is also used in clinical trials for other types of cancer.

What type of cytokine is IL-2?

Interleukin-2 (IL-2) is a pleiotropic cytokine that drives T-cell growth, augments NK cytolytic activity, induces the differentiation of regulatory T cells, and mediates activation-induced cell death.

Which of these cells produces IL-2?

Interleukin-2 production by dendritic cells and its immuno-regulatory functions. Dendritic cells (DCs) are uniquely potent antigen presenting cells that acquire microbial products and prime adaptive immune responses against pathogens. Furthermore, DCs also play a key role in induction and maintenance of tolerance.

Do cytotoxic T cells release IL-2?

Cytotoxic T cells both produce and respond to interleukin 2.

What are the side effects of IL-2?

Side effects of IL-2 can include flu-like symptoms such as chills, fever, fatigue, and confusion. Some have nausea, vomiting, or diarrhea. Many people develop low blood pressure, which can be treated with other medicines.

Is IL-2 an immunotherapy?

Interleukin-2 is an immunotherapy that activates the immune system to kill melanoma cells and shrink tumors wherever they develop in the body.

Is IL-2 a Th1 cytokine?

Although IL-2 has been characterized as a Th1-like cytokine, increasing evidence indicates that IL-2 and its downstream signaling molecule, Stat5, also are vital for the induction of anti-inflammatory Th2 cytokines during a primary response (2).