What is malignant granular cell tumor?
Malignant granular cell tumor (MGCT) is a rare high-grade mesenchymal tumor of Schwann cell origin. MGCTs commonly affect thigh, extremity, and trunk; however, involvement of the abdominal wall is quite rare. It has poor prognosis with 39% mortality rate in 3-year interval.
Is granular cell tumor painful?
These neoplasms are now considered to be of neural origin. The tumor is usually asymptomatic although some patients may experience mild pruritus or pain. A case of a large solitary painful GCT is reported here for its rarity.
What do granular cells do?
Granule cells are the smallest and most numerous type of neurons in the brain. They are involved in functions ranging from processing visual and motor information to learning and memory.
Do granular cell tumors grow?
Abstract. Granular Cell Tumours are rare mesenchymal soft tissue tumours that arise throughout the body and are believed to be of neural origin. They often present as asymptomatic, slow-growing, benign, solitary lesions but may be multifocal.
What causes granular cells?
Most granular cell tumors are benign, although some may be locally aggressive. Less than 2% are malignant, but these are aggressive and associated with a poor prognosis. Granularity of the cells in these tumors is due to the accumulation of secondary lysosomes in the cytoplasm.
Where are the granular cells?
Granule cells are found within the granular layer of the cerebellum, the dentate gyrus of the hippocampus, the superficial layer of the dorsal cochlear nucleus, the olfactory bulb, and the cerebral cortex.
What is a granular lesion?
Granular cell tumor (GCT) is a benign lesion characterized by the accumulation of plump cells with abundant granular cytoplasm. The formation of a granular cell tumor is a neoplastic process and the lesions formed are of neural derivation, as supported by immunophenotypic and ultra structural evidence.
What is granular cell tumor (GCT)?
Granular cell tumor (GCT) is a benign lesion that occurs at various sites of the body with preponderance to the oral cavity. The histogenesis of GCTs has remained enigmatic in spite of a vast number of immunohistochemical and ultra structural studies.
What is the history of granular cell myoblastoma?
INTRODUCTION In 1926 Arbikossoff described a tumor of the tongue composed of granular cells derived from striated muscles and termed it as granular cell myoblastoma, theory that was subsequently abandoned. Granular cell tumor (GCT) is a benign lesion characterized by the accumulation of plump cells with abundant granular cytoplasm.
What is abrikossoff’s tumor (GCT)?
Granular cell tumor (GCT), also known as Abrikossoff’s tumor, is a relatively uncommon neoplasm presenting as a benign, single, well-circumscribed nodule, usually arising on the tongue. Histologically, GCT shows numerous strands of large polyhedral granular cells, separated by collagen bundles, with no evidence of encapsulation.