What is normal P1NP level?
Adult male: 22-87 mcg/L. Adult female premenopausal: 19-83 mcg/L. Adult female postmenopausal : 16-96 mcg/L.
What does high P1NP mean?
When bone tissue is renewed, small fragments of the new collagen are found in the bloodstream, including P1NP. The higher the P1NP level in the blood, the more bone formation is taking place. P1NP levels rise within a few weeks when osteoporosis is being treated successfully with teriparatide.
What is low bone turnover?
Low turnover disease or adynamic bone disease (ABD) is characterized by a low number of osteoblasts with normal or reduced numbers of osteoclasts. Mineralization proceeds at a normal rate, resulting in normal or decreased osteoid thickness.
How long does a CTx blood test take?
About the Results Test results will be available approximately two weeks after your sample collection. If the test indicates an abnormal result, your healthcare provider will contact you.
Do I need to fast for CTx blood test?
The Serum CTX test requires fasting of 8-10 hours in advance of the blood sample being taken. For this reason, morning samples are preferred. For your convenience and to reduce wait times we recommend booking an appointment.
What is Propeptide type I collagen?
Procollagen type I propeptides are derived from collagen type I, which is the most common collagen type found in mineralized bone. In bone, collagen is synthesized by osteoblasts in the form of procollagen.
What does low P1NP mean?
Low PINP values are associated with a lower risk of fracture. It is not certain whether patients with low BTM have fracture benefit from treatment – one study with alendronate would indicate that there is no benefit (16), whereas a study with risedronate indicates there may be some benefit (54).
What is Adynamic bone disease?
Adynamic bone disease (ABD), a.k.a. aplastic lesion, is a histological condition found in uremic patients. It is characterized by low bone resorption and formation, and, in contrast to osteomalacia, the amount of osteoid tissue is normal or low.
What is the serum CTX test?
Information on the serum CTX Test. A test is available to help doctors and patients determine if patients taking bisphosphonates are at risk for osteonecrosis following dental treatment. This test is called the Collagen Type-1 C-Telopeptide (CTX)The serum CTX (C-Terminal Cross-Linking Telopeptide) measures the rate of bone turnover.
What does a high CTX level indicate?
For people who are not taking any medication for their osteoporosis, then a higher than normal level of CTx can indicate that there is a higher risk of bone fractures occurring.
Who can recommend a CTX blood test?
Only a medical provider can recommend a CTx blood test. After receiving the order for the test, there will be specific instructions to follow. A blood draw is required. Depending on the medical history, a follow-up order may also be issued for a 120-150 day return for a second blood test so the CTx results can be as accurate as possible.
What is a good CTX level for osteoporosis?
In some individuals, a 55% drop in CTx numbers have been documented. Improvements below 35% may also indicate progress, but require adjustment to the treatment plan. For people who are already taking osteoporosis medications and have been doing so for some time, the CTx blood test may not be helpful.