What is SoJIA?
Systemic-onset juvenile idiopathic arthritis (SoJIA) is a systemic inflammatory disease which has up to now been classified as a category of juvenile idiopathic arthritis.
How does rheumatoid arthritis affect ferritin levels?
Thus, serum ferritin is an index of iron stores also in rheumatoid arthritis. In active disease, higher than expected values of serum ferritin are probably due to a shifting of iron from the circulating pool to the reticuloendothelial cells of the synovial membrane.
Does arthritis affect ferritin levels?
Ferritin is an acute phase reactant and a marker of acute and chronic inflammation. It is elevated in a wide range of inflammatory conditions, including chronic kidney disease, rheumatoid arthritis, and other autoimmune disorders, acute infections, and cancer [1, 2].
What is the pathophysiology of juvenile rheumatoid arthritis?
JIA is a chronic rheumatic disease of childhood, characterised by progressive joint destruction and serious systemic manifestations. Complex interactions between immune cell populations, including lymphocytes, monocytes, macrophages and neutrophils, trigger the pathophysiological cascade in JIA.
Is juvenile idiopathic arthritis serious?
JIA often causes only minor problems, but in some cases it can cause serious joint damage or limit growth. Although JIA mostly affects the joints and surrounding tissues, it can also affect other organs, like the eyes, liver, heart, and lungs. JIA is a chronic condition, meaning it can last for months and years.
What is the difference between juvenile rheumatoid arthritis and juvenile idiopathic arthritis?
What Is Juvenile Rheumatoid Arthritis? Juvenile rheumatoid arthritis (JRA), often referred to by doctors today as juvenile idiopathic arthritis (JIA), is a type of arthritis that causes joint inflammation and stiffness for more than six weeks in a child aged 16 or younger.
Can rheumatoid arthritis cause high iron?
The chronic inflammation in RA leads to secretion of proinflammatory cytokines that influence iron metabolism. The parameters that are most affected are plasma iron levels and the production of transferrin, ferritin, and hepcidin.
What autoimmune diseases cause high ferritin levels?
Ferritin in autoimmune diseases Hyperferritinemia is known to be associated with autoimmune diseases, such as SLE, RA and MS [3–7], and also in serological antiphospholipid syndrome (APS) [8] (Table 1).
Can arthritis cause low ferritin?
The study shows that reduced marrow iron stores is common in patients with rheumatoid arthritis, and that the serum ferritin concentration may provide a useful indication of reduced body iron stores in these subjects, but only if a range of normal values can be established for this disease.
Does high ferritin cause joint pain?
In this journal article Bardou-Jacquet et al. report that individuals with HFE hemochromatosis can experience worse outcomes such as joint pain when the transferrin saturation percentage (TS%) is persistently elevated while the serum ferritin is within normal range.
What is the difference between juvenile idiopathic arthritis and rheumatoid arthritis?
JIA is arthritis that affects one or more joints for at least 6 weeks in a child age 16 or younger. Unlike adult rheumatoid arthritis, which is ongoing (chronic) and lasts a lifetime, children often outgrow JIA. But the disease can affect bone development in a growing child.
What are risk factors for juvenile idiopathic arthritis?
In our study, cigarette smoke exposure (intrauterine and after birth), exposure to O3 in the second year of life, and maternal occupational exposure were identified as potential risk factors for JIA, warranting further study.
What is systemic juvenile idiopathic arthritis?
Systemic juvenile idiopathic arthritis (SJIA) is a rare and serious subtype of juvenile idiopathic arthritis (JIA) that causes inflammation throughout the body. JIA is the most common type of arthritis in kids and teens.
Which proinflammatory cytokines play a major role in systemic juvenile idiopathic arthritis?
A growing body of evidence suggests that in active systemic JIA the proinflammatory cytokines that play a major pathogenic role are IL-6 [ 134, 135] and IL-1 [ 136 ], rather than TNF-α. Excellent responses of patients with the systemic subtype of JIA to the IL-1 receptor antagonist anakinra have been observed in uncontrolled studies [ 136, 137 ].
What are the diagnostic criteria for juvenile idiopathic arthritis (JIA)?
By definition, disease onset prior to the age of 16 years and arthritis persisting for longer than 6 weeks are required criteria for diagnosis of JIA (1,2). JIA represents a new, common name for several conditions considered separately in the past.
Does joint involvement predict progression in juvenile oligoarticular rheumatoid arthritis?
The early pattern of joint involvement predicts disease progression in children with oligoarticular (pauciarticular) juvenile rheumatoid arthritis. Arthritis Rheum.