What is the difference between Brexpiprazole and aripiprazole?
Aripiprazole has actions at 5HT2A, 5HT1A, and alpha 1B receptors that are less potent than its actions at D2 receptors, whereas brexpiprazole has actions at these 3 receptors equally or more potent than at D2 receptors (see Figures 4–6).
Is Brexpiprazole a sedative?
Brexpiprazole also has a moderate affinity for histamine H1 receptors relative to its D2 receptor affinity (Maeda et al., 2014), which could potentially result in low levels of sedation.
Is Brexpiprazole an antipsychotic?
Brexpiprazole is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substances in the brain.
Is Brexpiprazole a metabolite of aripiprazole?
Aripiprazole and brexpiprazole share a similar elimination half-life: approximately 75 hours and 94 hours for aripiprazole and its active metabolite dehydro-aripiprazole, respectively, and 91 hours and 86 hours for brexpiprazole and its major metabolite, DM-3411 (inactive), respectively.
Why does brexpiprazole cause weight gain?
Weight changes could be caused by changes in your metabolism while you’re using Rexulti. If your metabolism is affected by the drug, you may also have changes in your blood sugar, cholesterol, and triglyceride levels.
Does brexpiprazole cause weight gain?
While weight gain is common while on antipsychotic treatment, previous data reported patients on brexpiprazole was tied to an average 4.6 lb (2.1 kg) weight gain after 52 weeks.
Does brexpiprazole block dopamine?
Brexpiprazole has more blocking and less stimulating activity at the dopamine receptors than its predecessor, aripiprazole, which may decrease its risk for agitation and restlessness.
What is another name for brexpiprazole?
Rexulti (brexpiprazole) is an atypical antipsychotic, available in brand name. It is used to treat depression (in combination with an antidepressant medication) and schizophrenia.
Can you OD on brexpiprazole?
What happens if I overdose with Brexpiprazole? If an overdose occurs call your doctor or 911. You may need urgent medical care. You may also contact the poison control center at 1-800-222-1222.
How is Abilify different from Rexulti?
Abilify (aripiprazole) is good for treating psychosis and mania, and can help with depression. It’s less likely to cause side effects than other antipsychotics. Rexulti (brexpiprazole) does not cause as much weight gain as other similar medications. Fewer side effects compared to other similar medications.
What is brexpiprazole used for?
Brexpiprazole is an antipsychotic medication that is used to treat the symptoms of schizophrenia. It is also used together with other medications to treat major depressive disorder in adults.
What are the side effects of brexpiprazole?
Brexpiprazole side effects. signs of a blood clot–sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg. You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.
Can brexpiprazole be used to treat dementia?
Brexpiprazole is not approved for use in psychotic conditions related to dementia. Some young people have thoughts about suicide when first taking brexpiprazole. Stay alert to changes in your mood or symptoms.
How often should you titrate brexpiprazole?
Titration: Based on clinical response and tolerability, dose increases should be done at weekly intervals; titrate to 1 mg once a day, then up 2 mg once a day. What other drugs will affect brexpiprazole?