What is the difference between clopidogrel and ticagrelor?
Ticagrelor works more quickly than clopidogrel. Within 30 minutes, a 180mg loading dose of ticagrelor inhibited 41% of platelets. It takes almost 8 hours for clopidogrel 600mg to achieve this same effect. Maximum platelet inhibition (88% inhibition) was reached two hours after a dose of ticagrelor.
What type of antiplatelet is ticagrelor?
Ticagrelor is the first reversibly binding oral P2Y12 ADP-receptor antagonist for the treatment of ACS.
What is the mechanism of action of clopidogrel?
Mechanism Of Action Clopidogrel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets.
Why is ticagrelor more potent than clopidogrel?
Ticagrelor is a direct-acting oral antagonist of P2Y12-adenosine diphosphate (ADP) receptor blocker with reversibility and without catabolite activation, which can have a substantial impact on faster and greater platelet inhibition than clopidogrel [10, 11].
Is ticagrelor an anticoagulant?
Plavix (clopidogrel bisulfate) and Brilinta (ticagrelor) are anticoagulants (blood thinners) that inhibit aspects of blood clotting and are used to treat patients with acute coronary syndrome, heart attack (myocardial infarction), peripheral vascular disease, and ischemic strokes.
Is ticagrelor a blood thinner?
Brilinta (ticagrelor) is a blood-thinner used to reduce cardiovascular death and heart attack in patients with acute coronary syndromes (ACS). Brilinta works by preventing the formation of new blood clots, thus maintaining blood flow in the body to help reduce the risk of another cardiovascular event.
What is another name for ticagrelor?
Ticagrelor oral tablet is available as the brand-name drug Brilinta. It’s also available as a generic drug. Generic drugs usually cost less than the brand-name version. In some cases, the brand-name drug and the generic version may be available in different forms and strengths.
What is the use of ticagrelor?
Ticagrelor is an antiplatelet medicine. It makes your blood flow through your veins more easily. This means your blood will be less likely to make a dangerous blood clot. Taking ticagrelor can help prevent blood clots if you have an increased risk of having them.
Why is unfractionated heparin used in PCI?
Unfractionated heparin is the anticoagulant used most commonly in support of PCI. Glycosaminoglycans contained in unfractionated heparin bind to antithrombin resulting in the activation of antithrombin and potentiation of its effects on the coagulation cascade.
How is ticagrelor different from other antiplatelets?
Like the thienopyridines prasugrel, clopidogrel and ticlopidine, ticagrelor blocks adenosine diphosphate (ADP) receptors of subtype P2Y 12. In contrast to the other antiplatelet drugs, ticagrelor has a binding site different from ADP, making it an allosteric antagonist, and the blockage is reversible.
What is ticagrelor (cyclopentyltriazolopyrimidine)?
Ticagrelor, a cyclopentyltriazolopyrimidine derivative, is a nonthienopyridine, P2Y12 platelet adenosine diphosphate ( ADP )-receptor antagonist. In contrast to the thienopyridines (e.g., clopidogrel, prasugrel ), ticagrelor binds reversibly to the P2Y12 ADP receptor and does not require hepatic transformation to exert its pharmacologic effect.
What type of drug is ticagrelor?
Ticagrelor. Ticagrelor (trade name Brilinta, Brilique, and Possia) is a platelet aggregation inhibitor produced by AstraZeneca . Ticagrelor is an antagonist of the P2Y12 receptor. The drug was approved for use in the European Union by the European Medicines Agency on December 3, 2010.
What is the structure of ticagrelor?
Ticagrelor is a triazolopyrimidine that is an adenosine isostere; the cyclopentane ring is similar to ribose and the nitrogen-rich [1,2,3]triazolo[4,5-d]pyrimidine moiety resembles the nucleobase adenine.