What is the significance of a normal cytogenetic profile?
Early studies on MDS demonstrated that a normal cytogenetic profile was associated with a better prognosis, in contrast to AML, in which a normal karyotype correlates with an intermediate prognosis.
What is cytogenetic blood test?
Cytogenetics involves testing samples of tissue, blood, or bone marrow in a laboratory to look for changes in chromosomes, including broken, missing, rearranged, or extra chromosomes. Changes in certain chromosomes may be a sign of a genetic disease or condition or some types of cancer.
What is hematologic remission?
Hematologic remission (normal complete blood cell count [CBC] and physical examination (ie, no organomegaly) Cytogenetic remission (normal chromosome returns with 0% Philadelphia chromosome–positive (Ph+) cells)
What are cytogenetic abnormalities?
Definition. An irregularity in the number or structure of chromosomes, usually in the form of a gain (duplication), loss (deletion), exchange (translocation), or alteration in sequence (inversion) of genetic material. [ from NCI]
When would cytogenetic testing be used?
Cytogenetic testing is used in haematological cancers such as chronic myeloid leukaemia where a specific reciprocal translocation between chromosomes 22 and 9 results in the Philadelphia chromosome, that is present in 95% of cases.
What is hematologic response?
Hematologic response It’s done on a sample of blood taken from your arm. Complete hematologic response (CHR): This means your white blood cell and platelet counts have returned to normal, there are no immature cells seen in your blood, and your spleen is back to a normal size.
What is high risk cytogenetics?
Description. High Risk Cytogenetics is defined as one or more of t(4;14), t(14;16), or del 17p identified from FISH test results and is part of the staging criteria for plasma cell myeloma.