Which cells produce HGF?
It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes. HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its receptor, c-Met.
What stimulates HGF?
HGF, produced by some cancer cells, stimulates c-Met, through activation of the autocrine signaling system.
Is HGF a cytokine?
HGF is a pleiotropic cytokine produced by mesenchymal cells and macrophages. It is required for normal embryogenesis and development30,31 of several organs including the lung32.
What is HGF complex?
Abstract. Hepatocyte growth factor (HGF) is a paracrine hormone that plays an important role in epithelial-mesenchymal transition. HGF secreted by mesenchymal cells affects many properties of epithelial cells, such as proliferation, motility, and morphology. HGF has been reported to promote follicular growth.
What is HGF used for?
HGF plays essential roles in the embryonic development of the liver and placenta, and in the migration of myogenic precursor cells. In mature tissues, HGF plays roles in tissue protection and regeneration, including in the liver and kidney.
Where is HGF from?
Hepatocyte growth factor (HGF) is produced by stromal and mesenchymal cells, and it stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its cognate receptor, Met.
Is HGF a hormone?
Hepatocyte growth factor as cardiovascular hormone: role of HGF in the pathogenesis of cardiovascular disease.
Is TGF beta a cytokine?
Transforming growth factor β (TGF-β) is a highly pleiotropic cytokine that plays an important role in wound healing, angiogenesis, immunoregulation and cancer. The cells of the immune system produce the TGF-β1 isoform, which exerts powerful anti-inflammatory functions, and is a master regulator of the immune response.
What does C met stand for?
Biomarker Abbreviation: c-MET. Definition: also known as mesenchymal epithelial transition factor (MET) or hepatocyte growth factor receptor (HGFR) – a proto-oncogene active in cell signaling, c-MET promotes cancer cell growth and multiplication.
What are cytokines made of?
Cytokines are a large group of proteins, peptides or glycoproteins that are secreted by specific cells of immune system. Cytokines are a category of signaling molecules that mediate and regulate immunity, inflammation and hematopoiesis.
Is TGF pro or anti-inflammatory?
Transforming growth factor (TGF)b is most commonly considered an anti-inflammatory cytokine, a view that clearly does not correlate with the recently described role for TGFb1 in the differentiation of T-helper (Th)17 cells, a novel, highly inflammatory T-cell subset that produces interleukin (IL)-17.
What is RET mutation?
Mutations in the RET gene are the most common genetic cause of Hirschsprung disease, a disorder that causes severe constipation or blockage of the intestine. More than 200 RET gene mutations are known to cause this condition.