Which class is clindamycin?
Clindamycin is in a class of medications called lincomycin antibiotics.
What is the meaning of lincosamides?
lincosamide, any agent in a class of antibiotics that are derived from the compound lincomycin and that inhibit the growth of bacteria by blocking bacterial protein synthesis.
What group is lincomycin in?
Lincomycin is an antibiotic classified as a member of the lincosamide class, which typically features a L-proline amino acid derivative linked through amide group with an eight-carbon aminothio sugar.
What is the mechanism of action of lincosamides?
Mechanism of Action Lincosamides bind to the 50S ribosome in which they inhibit protein synthesis. Because this binding site is similar to that of chloramphenicol and the macrolides, concurrent use of these antimicrobials decreases overall efficacy; therefore combination therapy should be avoided.
What class is metronidazole?
Metronidazole belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth.
Is lincosamides bacteriostatic or bactericidal?
The lincosamides generally are considered bacteriostatic, although bactericidal activity can be demonstrated against certain organisms at antibiotic concentrations 2 to 4 times the minimum inhibitory concentration (MIC).
Are lincosamides broad spectrum?
Lincosamides are characterized by a fairly broad spectrum of activity against anaerobes, like Bacteroides species and a limited spectrum against aerobes. Many Gram- positive cocci are inhibited but most Gram-negative bacteria, mycoplasmas and strains of Clostridium difficile are resisistant.
What drugs are Lincosamides?
Lincosamides are a class of antibiotics, which include lincomycin, clindamycin, and pirlimycin.
Is lincomycin bacteriostatic or bactericidal?
Lincomycin and its semi-synthetic chlorinated derivative clindamycin are widely used in clinical practice. Both antibiotics are bacteriostatic, inhibiting protein synthesis in sensitive bacteria; however, at higher concentrations, they may be bactericidal.
Are lincosamides narrow or broad spectrum?
The two established members of the group of antibiotics known as the lincosamides, lincomycin and its semisynthetic derivative clindamycin, have a narrow antibacterial spectrum involving mostly Gram-positive species and some obligate anerobes, such as Bacteroides.
Is clarithromycin a quinolone?
Azithromycin, clarithromycin, and erythromycin were the administered macrolides, and ciprofloxacin, ofloxacin, levofloxacin, and moxifloxacin were the administered fluoroquinolones.
What are lincosamides?
Lincosamides are a class of antibiotics, which include lincomycin, clindamycin, and pirlimycin.
How many types of antibiotics are in the lincosamide group?
There are three antibiotics in the lincosamide group: lincomycin, pirlimycin and clindamycin.
What is the mechanism of action of lincosamides and macrolides?
Lincomycin and clindamycin bind exclusively to the 50S subunit of bacterial ribosomes and suppress protein synthesis. Lincosamides, macrolides, and chloramphenicol, although not structurally related, seem to act at this same site. The lincosamides are bacteriostatic or bactericidal depending on the concentration.
What is the difference between lincomycin and lincosamide?
(Note extra chlorine compared to lincomycin, but disregard inversion of image.) Lincosamides are a class of antibiotics, which include lincomycin, clindamycin, and pirlimycin. Lincosamides consist of a pyrrolidine ring linked to a pyranose moiety (methylthio-lincosamide) via an amide bond.