What are Osteolineage cells?
Osteolineage cells are derived from mesenchymal progenitor cells, and differentiate into several types of bone-forming cells. Of the various types of cell constituents in bone marrow, osteolineage cells have been shown to play important roles in hematopoiesis.
What are Nonhematopoietic cells?
Nonhematopoietic cells are the primary source of bone marrow-derived lung epithelial cells. Stem Cells.
What are mesenchymal stromal cells?
Mesenchymal stromal cells (MSCs) are a subset of heterogeneous non-hematopoietic fibroblast-like cells that can differentiate into cells of multiple lineages, such as chondrocytes, osteoblasts, adipocytes, myoblasts, and others.
What type of tissue is hematopoietic tissue?
Hematopoietic and Lymphoid Tissues The hematopoietic tissues arise from hematopoietic stem cells (HSCs) (Fig. 19.1), and include bone marrow, peripheral blood, and certain lymphoid tissue.
What are lymphoid-primed multipotent progenitors (lmpps)?
All lymphocytes are thought to develop from common lymphoid progenitors (CLPs). However, lymphoid-primed multipotent progenitors (LMPPs) are more efficient than CLPs in differentiating into T cells and group 2 innate lymphoid cells (ILC2s).
Do lymphoid progenitor cells express surface markers?
The common lymphoid progenitor cell is CD34+, CD10 +, CD45RA +, CD24 − and does not express surface markers for T-, B- or NK cells. B- and T-cells then undergo an orderly sequence of antigen expression during differentiation (see Tables 2.3 and 2.4 ).
Where do lymphoid progenitor cells mature?
Other lymphoid progenitor cells undergo maturation either in the bone marrow or in the fetal liver, where they become committed to immunoglobulin synthesis (B cells). Both B cells and T cells play an important role in the elimination of microbes.
What is the difference between leukemic stem cell (LSC) populations?
Both populations have leukemic stem cell (LSC) activity and are hierarchically ordered; one LSC population gives rise to the other. Global gene expression profiling shows the LSC populations are molecularly distinct and resemble normal progenitors but not stem cells.
