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What is an example of hypolipidemic drug?

Table of Contents

  • What is an example of hypolipidemic drug?
  • What drug class is used for hyperlipidemia?
  • What kind of medication is statin?
  • What are fibrates drugs?
  • What are the classifications of hypolipidemic drugs?

What is an example of hypolipidemic drug?

Statins are hypolipidemic drugs that block the enzyme HMG-CoA (5-hydroxy-3-methylglutaryl-coenzyme A) reductase, which is required for the synthesis of cholesterol. Examples of statins include simvastatin, pravastatin, and lovastatin.

What does a hypolipidemic drug treat?

Lipid-lowering agents, also sometimes referred to as hypolipidemic agents, cholesterol-lowering drugs, or antihyperlipidemic agents are a diverse group of pharmaceuticals that are used to lower the level of lipids and lipoproteins such as cholesterol, in the blood (hyperlipidemia).

What is the mechanism of action of the statin hypolipidemic drugs?

Mechanism of Action Statins work by competitively blocking the active site of the first and key rate-limiting enzyme in the mevalonate pathway, HMG-CoA reductase. Inhibition of this site prevents substrate access, thereby blocking the conversion of HMG-CoA to mevalonic acid.

What drug class is used for hyperlipidemia?

HMG-CoA Reductase Inhibitors (Statins) Statins are the most commonly prescribed lipid-lowering agents in the United States. They are generally effective, are supported by favorable outcome studies and have relatively few adverse effects.

What are lipoproteins used for?

Lipoproteins are substances made of protein and fat that carry cholesterol through your bloodstream. There are two main types of cholesterol: High-density lipoprotein (HDL), or “good” cholesterol. Low-density lipoprotein (LDL), or “bad” cholesterol.

Which of the following hypolipidemic drugs produce its effect by binding to bile acids *?

The bile-acid sequestrants–cholestyramine and colestipol–primarily decrease LDL cholesterol by binding bile acids, thereby decreasing intrahepatic cholesterol, and by increasing the activity of LDL receptors.

What kind of medication is statin?

Statins are drugs that can lower your cholesterol. They work by blocking a substance your body needs to make cholesterol. Lowering cholesterol isn’t the only benefit associated with statins. These medications have also been linked to a lower risk of heart disease and stroke.

What are 3 contraindications of statins?

having a history of liver disease. regularly drinking large quantities of alcohol. having a history of muscle-related side effects when taking a statin or fibrate (another type of medicine for high cholesterol) having a family history of myopathy or rhabdomyolysis.

What are the top 5 cholesterol medications?

Statins include:

  • Atorvastatin (Lipitor®)
  • Fluvastatin (Lescol. ®)
  • Lovastatin (Mevacor®)
  • Pravastatin (Pravachol®)
  • Rosuvastatin (Crestor®)
  • Simvastatin (Zocor®)

What are fibrates drugs?

Fibrates are medicines prescribed to help lower high triglyceride levels. Triglycerides are a type of fat in your blood. Fibrates also may help raise your HDL (good) cholesterol. High triglycerides along with low HDL cholesterol increase the risk of heart disease and stroke.

What happens when lipoprotein is high?

If you have high levels of lipoprotein(a) in your blood, it can stick to your artery walls and clog them up, leading to heart disease and stroke at a young age. Lipoprotein(a) is also known as Lp(a) for short. It’s passed on in your genes.

What are the 4 major classes of lipoproteins and what are their functions?

There are four major classes of circulating lipoproteins, each with its own characteristic protein and lipid composition. They are chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL).

What are the classifications of hypolipidemic drugs?

Classification of Hypolipidemic Drugs First Line Therapy 1. HMG-CoA reductase inhibitors (Statins): Lovastatin, Simvastatin, Pravastatin, Atorvastatin, Rosuvastatin, Pitavastatin 2. Bile acid sequestrants (Resins): Cholestyramine, Colestipol 3. Inhibitors of Intestinal Absorption of Cholesterol: Stanol Esters, Ezetimibe.

How do hypolipidaemic drugs work?

• Hypolipidaemic drugs lower the levels of lipids & lipoproteins in blood. • Lipids are transported in plasma in lipoproteins, which are associated with several proteins called as apoproteins. 2 3. • Lipoproteins are divided based on their particle size & density . 3

What are the adjuvants used to treat hypovolemic shock?

• H1 antagonists & glucocorticoids are used as adjuvants Neurogenic shock • Rx similar to hypovolemic shock. • Norepinephrine/phenylephrine to maintain BP. 40 41. Plasma expanders • Ideally human plasma/whole blood or reconstituted human albumin are preferred to correct hypovolemia due to hemorrhage.

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